A new potential analog of cortisol is being synthesized that is not membrane permeable. Is this analog likely to function in a similar manner to cortisol?

Post a problem or question on the discussion board that your peers can respond to critically.
The question or problem should be grounded on information from previous units.
It should require the learner to apply basic information from the course in a higher order of thinking (i.e. the answer should not be attainable purely from the text or lectures)
For example (please do not use these examples):
In an experiment, a valine is mutated to a glutamic acid in a transmembrane domain of a protein. What is the likely consequence of this single amino acid change?
A new potential analog of cortisol is being synthesized that is not membrane permeable. Is this analog likely to function in a similar manner to cortisol?